Pharmaceutical Science

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The Inhibitor Index: A Desk Reference on Enzyme Inhibitors, Receptor Antagonists, Drugs, Toxins, Poisons, Biologics, and Therapeutic Leads

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Daniel Purich
June 12, 2017

Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a proce...

Phage Display In Biotechnology and Drug Discovery, Second Edition

Sachdev S. Sidhu, Clarence Ronald Geyer
October 16, 2017

Phage Display in Biotechnology and Drug Discovery, Second Edition provides a comprehensive view of the impact and promise of phage display in drug discovery and biotechnology. Building on the success of its previous edition, the book discusses current theories, principles, and methods in the field...

Sedimentation Velocity Analytical Ultracentrifugation: Interacting Systems

Peter Schuck, Huaying Zhao
October 04, 2017

Analytical ultracentrifugation is one of the most powerful solution techniques for the study of macromolecular interactions, to define the number and stoichiometry of complexes formed, and to measure affinities ranging from very strong to very weak and repulsive. Building on the data analysis...

Biosimilars and Interchangeable Biologics: Strategic Elements

Sarfaraz K. Niazi
September 30, 2017

What’s the Deal with Biosimilars? Biosimilars are gaining momentum as new protein therapeutic candidates that can help fill a vital need in the healthcare industry. The biological drugs are produced by recombinant DNA technology that allows for large-scale production and an overall reduction time...

Toxicologic Pathology: Nonclinical Safety Assessment

Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath
September 30, 2017

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical...

RNA Nanotechnology and Therapeutics

Peixuan Guo, Farzin Haque
September 30, 2017

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in...

Handbook of Statistics in Clinical Oncology, Third Edition

John Crowley, Antje Hoering
September 12, 2017

Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been...

Dermatokinetics of Therapeutic Agents

S. Narasimha Murthy
September 12, 2017

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, allows certain topically applied substances and toxins to pass. The dermatokinetics of a drug determines the efficacy of...

Embedding New Technologies into Society: A Regulatory, Ethical and Societal Perspective

Diana M. Bowman, Elen Stokes, Arie Rip
September 11, 2017

The embedding of any new technologies in society is challenging. The evolving state of the scientific art, often-unquantifiable risks and ill-defined developmental trajectories have the potential to hinder innovation and/or the commercial success of a technology. The are, however, a number of tools...

Cancer Vaccines: From Research to Clinical Practice

Adrian Bot, Mihail Obrocea, Francesco M. Marincola
September 11, 2017

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first...

Biomedical Application of Nanoparticles

Bertrand Henri Rihn
September 06, 2017

Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms,...

Sample Size Calculations in Clinical Research, Third Edition

Shein-Chung Chow, Jun Shao, Hansheng Wang, Yuliya Lokhnygina
August 30, 2017

Praise for the Second Edition: "… this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics "This impressive book contains formulae for computing sample size...

Carrier-Mediated Dermal Delivery: Applications in the Prevention and Treatment of Skin Disorders

Andreia Ascenso, Helena Ribeiro, Sandra Simões
August 18, 2017

This book presents new approaches for skin aging and photocarcinogenesis and topical formulations based on nanocarrier systems for skin disorders. It discusses cosmeceuticals, laser, photodynamic therapy, and melatonin-based treatments as important strategies for photoaging management. Photodynamic...

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